Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes: DISCUSSION (part 4)

Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes

To our knowledge, the precise binding site or sites for fle-cainide on the L-type channel in cardiac cells have not yet been determined. In recent experiments using cloned neuronal calcium channel subunits, Zamponi et al investigated ICa,L block by flecainide and the structurally related compound fomocaine. By changing the concentration of barium (the permeant ion…

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