Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes (part 5)

Generation of protocols, data acquisition and analysis: Specific voltage clamp protocols are detailed in the relevant Results sections. Voltage clamp command signals were generated by a Cambridge Electronic Design (Cambridge, United Kingdom) 1401 interface and WCP (a program written and supplied free of charge by John Dempster of Strathclyde University). Data were recorded directly online…

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Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes (part 4) / buy zoloft online

Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes

Electrophysiological recording: The whole cell patch clamp technique was used for electrophysiological measurement. Patch-pipettes (Corning 7052 glass, AM Systems Inc, Carlsborg, Washington, USA) were pulled to resistances of 1 to 3 МП (Narishige PP83 puller, Tokyo, Japan) and fire-polished to 4 to 6 МП (Narishige MF83 microforge). A predominantly cesium-based internal dialysis solution blocks outward…

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Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes (part 1)

Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes

The atrioventricular node (AVN) plays a key role in cardiac conduction. It normally constitutes the primary route for conduction of the cardiac impulse from atria to ventricles and exhibits slowed electrical conduction relative to other cardiac regions . Slowed AVN conduction facilitates ventricular filling during atrial systole and is of considerable importance during supraventricular tachycardias…

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