Six of the cases had recurrent admissions for LRTI. Admissions were primarily clustered in infancy and some required paediatric intensive care (Table 3). There were three mortalities in the case series that were secondary to overwhelming infections, of which two were percipitated by a LRTI.

The present case series suggests that among hospitalized patients there is a high morbidity and mortality associated with CAA. High rates of preterm birth, SGA and LRTI suggest that albumin plays an important role in placental function, development of the respiratory system and immunity. All cases received albumin infusions; however, there were insufficient data to determine if this had an effect on morbidity or mortality. The hospitalized child with CAA may have increased susceptibility to fluid overload, hypocalcemia and hypomagnesemia. We are not able to make any conclusions about management of CAA patients or their long-term health risks. We support collaboration between local communities and academic centres to identify priorities to optimize care and determine the longitudinal implications of CAA. It’s time to pay less money – just get generic sildenafil online just buy now at the best online pharmacy.

TABLE 3 Medical history

Case NICU Admission(s) Recurrent LRTI* PICU Admission(s) Other medical diagnosis
1 Yes Yes No Symptomatic neonatal hypoglycemia, chronic otitis media, asthma
2 No No No Milk protein allergy
3 Yes No Yes Epilepsy and developmental delay, chronic otitis media, 2nd degree burns
4 Yes Yes Yes Persistent patent ductus arteriosus, bilateral grade III intraventricular hemorrhage, death
5 Yes Yes Yes Neurometabolic disorder, bilateral cataracts, sensorineural hearing loss, cerebral palsy, death
6 Yes Yes Yes Neurometabolic disorder, symptomatic vitamin D deficiency, death
7 Yes Yes No Developmental delay
8 Yes No Yes Hemangioendothelioma
9 No No No Persistent patent ductus arteriosus
10 Yes Yes Yes Pulmonary hemorrhage and chronic lung disease, gross motor developmental delay
11 Yes Not No None

*Recurrent lower respiratory tract infection (LRTI) is defined as >3 LRTI requiring hospitalization before 1 year of age; fThis case was

Category: Congenital analbuminemia / Tags: Analbuminemia, Indians, infant, Intensive care, Low birth weight, Neonatal, Newborn, North American, Oligohydramnios, Paediatric, Premature, Respiratory tract infections, Small for gestational age

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