chronic non-advanced liver disease


Metabolic bone disease is a complication of chronic liver dis­ease (CLD) and is well known as “hepatic osteodistrophy”. Osteoporosis accounts for the majority of cases, whereas osteomalacia is rare in the absence of advanced liver disease and severe malabsorption. The prevalence is the same in men and women, however the published prevalence of os­teoporosis considerably differs and ranges from 20% to 100%, depending on patients selection and different diagnostic criteria. Many reports are referred to a broad spectrum of liver disease of different aetiology and severity: in patients with ad­vanced liver disease candidates for or treated with orthotopic liver transplantation, osteoporosis is prevalent and contributes to a major source of morbidity preceding and following trans­plantation. Nevertheless, little is known about the preva­lence among patients with non-advanced liver disease. The ae­tiology and pathogenesis of osteoporosis in these patients also remain undefined, even though its histology is quite similar to post-menopausal and age-related bone loss, affecting trabecu­lar bone more rapidly than cortical bone. Finally, there is controversy about risk factors for osteoporosis in CLD: liver cir­rhosis, cholestasis, hypogonadism, corticosteroid or immuno- suppressive treatment, alcohol consumption, malnutrition and malabsorption, sex, physical activity, subnormal vitamin D lev­els and/or vitamin D receptor genotype, insulin growth factor 1 (IGF-1) deficiency, as well as country and nationality are all re­ported factors affecting bone metabolism. However, whether non-advanced liver disease “per se” could be a risk factor for osteoporosis still remains uncertain; more­over there are few reports about the effects of viral liver dis­ease on bone turnover.

Aim of this study was to evaluate bone mineral density (BMD) and bone metabolism markers in a selected series of male pa­tients living in the same geographical area of Southern Italy, af­fected only by viral, non-advanced chronic liver disease, as compared to a randomly selected control group from the same geographical area. Going without your pills? where to buy cialis


Category: Diseases / Tags: liver disease, men, osteoporosis

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