Clinical and laboratory data of patients and controls are report­ed in Table I.

BMD was reduced in 16 (64%) out of 25 patients: 5 patients (20%) could be classified as osteoporotic and 11 patients (44%) osteopenic on the basis of at least one measurement. Table II reports mean BMD values for lumbar spine (LS) and femoral neck (FN) in patients and controls, showing a de­creased BMD in patients in both sides of measurements even if only for the LS it reaches the significance. In order to compare the BMD of our patients with reference population data we calculated the 95% CI of the mean Z-score at the LS and at the FN. Data showed that the mean Z-score at LS but not at FN among liver patients was significantly lower as compared to the age- and sex-matched general population (lumbar spine mean Z-score 95% CI = -1.06 to -0.920; femoral neck mean Z-score 95% CI = -0.54 to + 0.53). Using multiple linear regression analysis we investigated the relationship between BMD (gr/cm2) and the variables consid­ered, including the time of detection of abnormal tests of liver function. No correlation was found between BMD and the vari­ables studied.


Table I – Clinical features and liver function laboratory tests.

Patients (25)

Controls (30

Age

50.4 ± 8.4

51.2 ± 3

BMIkg/m2

26.4 ± 4.6

26.2 ± 3.1

Albumin (g/dl)

4.0 ± 0.5

4.2 ± 0.3

GGT (U/L)

72 ± 11

30 ± 8

Prothrombin time (%)

79 ± 9

98 ± 2

AST (U/L)

90 ± 12

23 ± 6

ALT (U/L)

85 ± 10

25 ± 5

Total bilirubin (mg/dl)

0.7 ± 0.4

0.6 ± 0.4

Alkaline phosphatase (U/L)

155 ± 11

150 ± 7

Biochemical tests of bone remodelling metabolism and hor­monal profiles did not differ in the two groups. Make your pharmacy dollar go further and buy generic cialis mastercard online

Table II – BMD in liver patients and controls.

Mean values

Patients

Controls

Lumbar Spine (L1-L4) BMD (gr/cm2) 0.08*

0.992 ± 0.18

1.11 ±

Femoral neck BMD (gr/cm2)

0.858 ± 0.05

0.849 ± 0.15

* P = 0.0254.

Category: Diseases / Tags: liver disease, men, osteoporosis

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