iron overload

INTRODUCTION

Cancer of the prostate is the most common non-skin cancer in American men and the fourth most common cancer in men throughout the world. In 2003, 220,900 new cases are expected to be diagnosed in the United States, and 28,900 deaths are anticipated. In addition to a family history of prostate cancer (PC), race, age, and certain dietary factors have been reported to increase the risk for PC. Increased consumption of foods high in ani­mal fat and an increased proportion of calories from animal fat have also been associated with a high risk for PC in all races. In contrast, certain antioxidants, such as selenium and zinc, have been suggested to play a protective role for PC.

A number of clinical, epidemiological, and experimental studies suggest that elevated body iron stores increase the risk of cancer overall and, specifically, cancer of the liver, lung, colon-rectum, esophagus, gastrointestinal tract, and pancreas. Data collected during the first National Health Assessment and Nutritional Examination Survey (NHANES I) conducted in the United States between 1971 and 1975 also suggested that moderate elevations of body iron stores assessed by transferrin saturation (TS) above 40%, were associated with increased risk and mortality from cancer. canadian drugstore online

There are two possible mechanisms by which iron may increase the risk of cancer. The first is by increasing the production of free radicals thought to be carcinogenic and the second by regulating the activity of ribonucleotide reductase, the rate-limiting enzyme in the DNA synthesis pathway and, hence, cell proliferation. Indeed, iron chelation by deferoxamine inhibits the proliferation of tumor cells and normal lymphocytes, and also induces apoptosis. There is a paucity of information on iron status and risk of PC. Therefore, the present study was designed to determine whether elevated body iron stores defined as serum ferritin >300 mg/L and/or TS>50% are associated with increased risk of PC. In the present study, we report for the first time that there is a negative correlation between body iron status and risk of PC.

Category: Cancer / Tags: iron deficiency, iron overload, prostate cancer, serum ferritin, transferrin saturation

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