rabbit atrioventricular nodal myocytes (part 11)

In the presence of flecainide 100 pM, V0.5 was -6.3±0.3 mV (P<0.005) and k was 5.9±0.2 mV (P<0.01). Thus, flecainide decreased in the mag nitude of ICa,L and produced a small negative voltage shift in current activation. These observations correlate well with a previous study on amphibian ventricular myocytes that showed decreased ICa,L amplitude and a leftward shift of the current-voltage relation for ICa,L following flecainide application .The effect of flecainide 100 pM on ICa,L differed with the magnitude of the test depolarization (Figure 3B). Between -30 and +40 mV, the level of block was quantified by plotting the degree of current inhibition (I-[IFlec/IControl], where IFlec is the flecainide current and IControl is the control current) against membrane potential (Figure 3C). Flecainide inhibition of ICa,L increased with test pulse amplitude, and regression analysis showed a strong correlation between fractional inhibition and magnitude of test depolarization (with r and r values of 0.98 and 0.96, respectively). A similar relationship between fractional inhibition and test potential was seen from cell to cell, and this observation is consistent with the voltage-dependent block of ICa,L by flecainide reported previously for frog myocytes by Scamps et al . Buy drugs with confidence – canadian cialis online to see how cheap your treatment can be.

Category: Antiarrhythmic agents Cardiology / Tags: Antiarrhythmic agents, Atrioventricular node, Flecainide, L-type calcium current, Single cell

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