rabbit atrioventricular nodal myocytes (part 1)

The atrioventricular node (AVN) plays a key role in cardiac conduction. It normally constitutes the primary route for conduction of the cardiac impulse from atria to ventricles and exhibits slowed electrical conduction relative to other cardiac regions . Slowed AVN conduction facilitates ventricular filling during atrial systole and is of considerable importance during supraventricular tachycardias (SVTs) such as atrial fibrillation (AF). In AF, slowed AVN conduction limits the number of impulses that are transmitted to the ventricles, thereby protecting, to some extent, ventricular function and cardiac output . Therefore, due to its critical location and role, the AVN is an important site of an-tiarrhythmic drug action.
Flecainide is a class Ic antiarrhythmic agent used in the treatment of a variety of SVTs. You should always visit the best pharmacies to get your medications cheap and safely. You will find this my canadian pharmacy to be particularly advantageous and safe, buying any drugs required in just a few minutes. It is effective in the prophylaxis and treatment of AF and is used in the treatment of arrhythmias involving the AVN. Flecainide administered intravenously, for example, can terminate AVN reentrant tachycardia in a large percentage of patients; however, it can be associated with side effects, including AVN block and bundle branch block . There is some heterogeneity of the action potential throughout the AVN ; however, evidence from single cell AVN experiments, as well as from multicellular preparations and the intact perfused heart, suggests that, in a significant proportion of cells, the action potential upstroke is carried by L-type calcium current (ICa,L).

Category: Antiarrhythmic agents Cardiology / Tags: Antiarrhythmic agents, Atrioventricular node, Flecainide, L-type calcium current, Single cell

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