The staining to alpha-fetoprotein and Bcl-2 antibodies re­mained consistently negative to very weak in all parts of the tumour in all cases. Moderate to strong P53 staining was ob­served in 17 (89%) of the in situ component and 24 (86%) of the invasive components (Table 2). CEA staining was ob­served in both the in situ (84%) and invasive (89%) compo­nents (Table 3). The immunoreaction was strong and present along the cell surface, within the cytoplasm and in the gland secretions (Figures 3A,B).

Figure 3)ACarcinoembryonic antigen staining

Figure 3) A Carcinoembryonic antigen staining is restricted to the apical cytoplasm in the carcinoma in situ component. B Carcinoembryonic antigen staining is stronger and can be seen within the cytoplasm and even within the gland secretions in the invasive components of gallbladder carcinoma

The in situ staining patterns of P53 were statistically in­significant to their mean survival. However, moderate to strong staining of the invasive components, as seen in 15 cases (54%), was associated with a mean survival of 8.8 months (Table 2). Get smart and save money! Buy generic cialis online

TABLE 2 P53 staining profile

In situ
component

(n=19)

Invasive
component (n=28)

P53 staining

Number

alive (months)

Number

dead (months)

Number

alive (months)

Number

dead (months)

Strong (+ ++)

2 (58.5)

4 (24.5)

2 (58.5)

8 (9.4)

Moderate (++)

N/A

5 (3.2)

1 (64)

7(8.3)

Weak (+)

N/A

6 (13.5)

2 (13.5)

4 (13.3)

Negative

2 (60)

N/A

1 (56)

3 (10)

CEA staining of both the in situ and invasive compo­nents were associated with a mean survival of 10.6 months in 76% of the cases (Table 3).

TABLE 3 Carcinoembryonic antigen (CEA) profile

In situ
component

Invasive
component

(n

= 19)

(n

=28)

Number

Number

Number

Number

alive

dead

alive

dead

CEA staining

(months)

(months)

(months)

(months)

Strong (+ ++)

1 (19)

7 (11.4)

4 (59.3)

11 (8.8)

Moderate (++)

1 (98)

5 (15.4)

2 (13.5)

8 (12.5)

Weak (+)

N/A

2 (16)

N/A

N/A

Negative

2 (60 m)

1 (6 m)

N/A

3 (6.3)

Category: Cancer / Tags: Alpha-fetoprotein, Bcl-2, Carcinoembryonic antigen, Gallbladder carcinoma, P53

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