RESULTS(2)

Experiment 2

Both SD and FR inhibited testicular growth (F = 153.9, p < 0.0001, and F = 56.1, p < 0.0001, respectively; Fig. 4). The effects of photoperiod and of food restriction were significant at Week 1, and both persisted through all 13 wk of the study (Fig. 4). There was a significant interaction between SD and fR treatment (F = 19.2; p < 0.001), showing that FR treatment enhanced the inhibitory effect of SD (Fig. 4). At the time of their greatest differences, at Weeks 3 and 5, the combined effect of SD and FR resulted in testes approximately 70% smaller than the LD controls. buy diabetes drugs

Both SD and FR treatment affected increases in body weight (F = 153.1, p < 0.0001, and F = 576.4, p < 0.0001, respectively; Fig. 5). The effect of food was significant after 1 wk, and the effect of SD was significant after 3 wk (Fig. 5). There was a significant interaction between SD and fR treatment (F = 9.2; p < 0.005). The interaction is difficult to interpret, but it appears that FR enhanced the inhibitory effect of SD on body weight in the second half of the experiment, while in early weeks the effects of FR and SD were essentially additive. Control SD rats weighed 10-25% less than control LD rats in most weeks, while FR rats weighed about 20% less than ad lib controls in the same photoperiod (Fig. 5).
Fig4Food and Neonatal
FIG. 4. Mean testis volume (mean ± SE) over 1 3 wk for male F344 rats given food ad lib or 30% food restriction and held in SD or LD from weaning (n = 8-10 per group). For each measurement period, different lowercase letters above bars indicate significant differences (p < 0.05) between treatments.

Fig5Food and Neonatal1
FIG. 5. Mean body weight (mean ± SE) over 1 3 wk for male F344 rats given food ad lib or 30% food restriction and held in SD or LD from weaning (n = 8-10 per group). For each measurement period, different lowercase letters above bars indicate significant differences (p < 0.05) between treatments.

Category: Androgen / Tags: Androgen, Neonatal, Rats, Reproductive Maturation