Monocyte chemoattractant protein-1 (MCP-1) is a member of the intercrine (3 family of cytokines. The cytokines in this group are thought to be involved in inflammation and tissue repair. MCP-1 is produced by a variety of cell types including fibroblasts, endothelial cells, lymphocytes, and macrophages and is involved in the cellular immune response as well as response to tissue damage. It is a specific chemoattractant for monocytes when injected into the ears of rats and acts as a chemoattractant for monocytes in vitro. A variety of growth factors and cytokines such as tumor necrosis factor a and interleukin-1 stimulate MCP-1 mRNA expression and secretion of the active protein. buy cipro
In recent years it has been suggested that cytokines, in particular the cytokine products of immune cells, may be involved in controlling ovarian function. The properties of specific monocyte attraction and production by cell types that are abundant in luteal tissue first led workers to consider a role for MCP-1 in initiating the influx of macrophages that is observed in the late-stage corpus luteum (CL).