heparin is commonly administered to cardiac patients, particularly those with acute coronary syndromes. This drug has proven effective for the prevention and treatment of venous thrombosis and pulmonary embolism, for the prevention of mural thrombosis after myocardial infarction, and for the treatment of patients with unstable angina and myocardial infarction.

Data from the GUSTO-I trial demonstrated that therapeutic anticoagulation was associated with lower reinfarction and mortality rates after acute myocardial infarction. In addition, a higher incidence of moderate or severe bleeding and reinfarction was observed among patients with higher activated partial thromboplastin time (aPTT).

To reduce the time to therapeutic anticoagulation and to increase the time spent in the therapeutic range, many institutions have developed and used titration protocols. The main objective of this study was to evaluate compliance by physicians and nursing personnel in applying such a protocol for patients with acute coronary syndromes. Two secondary objectives were to evaluate the time required to reach therapeutic aPTT and the time spent in the therapeutic aPTT range.
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Category: Diseases / Tags: acute coronary syndromes, heparin, titration protocol

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