This was a prospective observational study carried out at the Medical Outpatient (MOP) Clinic of the State Hospital, Abeokuta, Nigeria, from February 2002 to January 2003. The study population consisted of 185 consecutive patients (65 males, 120 females) with primary hypertension who had been on drugs one- to 25 years prior to the onset of the study. These patients were subsequently followed for the study period. A patient was considered hypertensive if he or she was already receiving antihypertensives or has persistently elevated SBP >140 mmHg and/or DBP >90 mmHg. Secondary hypertension was excluded by the findings of normal routine blood chemistry, normal urinary sed iments, and normal renal ultrasonography.
Data were collected using a standard questionnaire to obtain information on age, gender, duration of hypertension, and the number of drugs taken for hypertension. An examining physician, using a mercury column sphygmomanometer with appropriate cuff sizes after the patients have rested for a period of five minutes, measured blood pressure at each clinic visit. Korotkoff’s sounds I and V were taken as the SBP and DBP, respectively. Two BP readings were taken at intervals of two minutes at each clinic visit and the average calculated. Patients were seen at monthly intervals during the period of study. Six consecutive clinic BP values were recorded for each patient and the average calculated (SBP and DBP separately). The values obtained were used for subsequent analysis. cheap prescription drugs online
Based on the mean of the six consecutive readings, subjects were classified as having:
• Controlled SBP and DBP if current antihypertensives treatment was accompanied by clinic SBP <140 mmHg and a clinic DBP <90 mmHg;
- Controlled SBP only if SBP is < 140 mmHg and DBP >90 mmHg;
- Controlled DBP only if DBP is <90 mmHg and SBP is>140 mmHg;
- Uncontrolled SBP and DBP if SBP and DBP are >140 mmHg and >90 mmHg respectively.
- The group of patients with controlled SBP and/or
DBP were further classified into:
- Those with SBP <140 mmHg and
- Those with DBP <90 mmHg.
Continuous variables were displayed as means and standard deviation (SD), and categorical variables were displayed as percents. Data were also stratified using age groupings (35-49, 50-64, >65 years). Differences between means were assessed by student’s t test and differences between categorical variables by chi-square test. Statistical significance was considered to be p<0.05.
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