The serotonin syndrome. A tabular guide: TREATMENT OF THE SEROTONIN SYNDROME

TREATMENT OF THE SEROTONIN SYNDROME Discontinuation of the suspected serotonergic agents will often result in the syndrome resolving within 24 h. In case of over dose, pre ven tion of ab sorp tion using gastric lavage with activated charcoal and magnesium citrate is recommended. For more severe cases, supportive measures such as cooling blankets for…

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The serotonin syndrome. A tabular guide: DIFFERENTIAL DIAGNOSIS(3)

AD_021

Hypertensive crisis Hy per ten sive crisis, an ad verse drug event, is char acter -ized by a severe, often throbbing, occipital headache which may radiate frontally. Nausea and vomiting, neck stiffness, palpitations, diaphoresis and even fever may occur. A hypertensive crisis can occur when an irreversible monoamine oxidase inhibitor (isocarboxazid [not available in Canada],…

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The serotonin syndrome. A tabular guide: DIFFERENTIAL DIAGNOSIS(2)

Lethal catatonia Lethal catatonia is a psychiatric condition unrelated to medication use, consisting of a prodromal phase of psychomotor agitation that persists for days to weeks before pro-gresstng to a severe state of psychosis with refusal to eat or drink, profuse perspiration, fever, muscle tension or rigidity, and eventual cardiac collapse leading to coma and…

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The serotonin syndrome. A tabular guide: DIFFERENTIAL DIAGNOSIS(1)

MECHANISM The 5-HT-1A receptor is responsible in large part for the serotonin syndrome, with enhancement of overall 5-ht neurotransmission as a necessary, but possibly not sufficient, cause. Not every patient with elevated brain 5-ht levels der velops the serotonin syndrome, but the potentially fatal outcome warrants precautions when combining serotonergic agents.

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The serotonin syndrome. A tabular guide: CLINICAL FEATURES

diseases_Serotonin-syndrome

The serotonin syndrome is an adverse drug event caused by excessive enhancement of serotonin (5-ht) neurotransmission characterized by at least three of the following: mental status changes (confusion, hypomania), agitation, myoclonus, hyper-reflexia, diaphoresis, shivering, tremor, diarrhea, incoordination and fever.

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