Risks and benefits of Helicobacter pylori eradication: BACKGROUND Part 2

Helicobacter pylori

Despite considerable advances in knowledge about the relationship between H pylori infection and the human host, many aspects of the host response remain unknown. It is not known why so many infected individuals do not develop clinically significant disease. Indeed, there is speculation that, in some individuals, there may be a symbiosis between the presence…

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Risks and benefits of Helicobacter pylori eradication: CONCLUSIONS

CONCLUSIONS

The relationship between H pylori infection and the human host is proving to be complex. Risks posed by infection may involve differences in host susceptibility and relative virulence of H pylori strains, as well as other factors yet to be identified. Although some patients tolerate life-long infection without apparent clinical consequences, it is important to…

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Risks and benefits of Helicobacter pylori eradication: GASTRIC PATHOLOGY Part 2

GASTRIC CANCER

Controversies surrounding the possible relationship among H pylori infection, GERD and PPI therapy were not addressed in the 1999 revised guidelines. However, the available data do not permit definitive statements to be made. The risk posed by eradication of H pylori infection for GERD has not been proven, and would not preclude treatment in the…

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Risks and benefits of Helicobacter pylori eradication: GASTRIC PATHOLOGY Part 1

GASTRIC CANCER

The hypothesis that eradication of H pylori infection in duodenal ulcer patients increases the risk of GERD remains very controversial. The potential for H pylori infection of the fundus of the stomach to provide protection against GERD is one of the most frequently cited examples of a possible symbiosis between infection with this organism and…

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Risks and benefits of Helicobacter pylori eradication: GASTRIC CANCER

GASTRIC CANCER

Epidemiological evidence indicates that H pylori infection increases the risk of gastric adenocarcinoma by a multiple of 1.7 to 4.0. Postulated mechanisms include changes in the cell cycle, molecular characteristics and alterations in immune function induced by chronic gastritis, together with environmental factors. Chronic gastritis may progress to mucosal atrophy, intestinal metaplasia and then dysplasia,…

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