EFFECT OF DRUG VINTAGE: Summary

The Puerto Rico Health Insurance Administration (ASES) contracts with private managed care organizations to provide health care services for approximately 1.5 million people, or 40% of the population of Puerto Rico. We examined the impact of the vintage (original FDA approval year) of drugs used to treat a patient on the probability of survival, conditional…

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EFFECT OF DRUG VINTAGE: Empirical results 2

The first column of Table 2 shows estimates for the entire population (copied from Table 1). The coefficients of the three drug-vintage variables (lines 11, 12, and 13) indicate differences between the mortality rates of people using drugs of different vintages. By combining these coefficients with the average mortality rate (line 3) and the vintage…

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EFFECT OF DRUG VINTAGE: Empirical results

For example, one additional medical claim (physician visit) is associated with a.0031 (about 8%) increase in the probability of death. Although utilization of medical services presumably reduces mortality, given initial (pre-treatment) health status, people in the worst initial health utilize the most medical services. Including the three utilization variables (as well as the diagnosis category…

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EFFECT OF DRUG VINTAGE: Data and measurement 2

The three-year mortality rate is 3.1%. This seems consistent with published mortality data for Puerto Rico. According to the United Nations, the crude (annual) death rate in Puerto Rico during 2000-2005 under “medium variant” mortality assumptions is 8.3 per 1,000 population.6 This implies a three-year mortality rate of approximately 2.49% (= 3 * 0.83%). Mortality…

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EFFECT OF DRUG VINTAGE: Data and measurement

ASES provided me with all medical and pharmacy claims of ASES beneficiaries during the period January 1-June 30, 2000. There were about 12.2 million claims. Demographic information. The following demographic variables could be determined from the claims records: • The person’s sex • The person’s age • The geographic region in which services were provided…

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EFFECT OF DRUG VINTAGE: Introduction

Clinical studies of specific new drugs have shown that these drugs increase survival rates. Here are three examples: • Stenestrand et al studied the impact on survival of statin treatment following acute myocardial infarction. They found that 1-year mortality was 9.3% in the no-statin group and 4.0% in the statin treatment group. • Grier et…

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