The first smallpox epidemic on the Canadian Plains: part 3

December 1781 17th Monday. I received the Disagreeable News of that Devouring Disorder the small pox rageing amongst the Natives & is carrying all off before It… “Copy of a Letter received from Mr William Walker, Hud- sons House [built by William Tomison in 1788, 370 km up­stream from Cumberland House on the North Saskatchewan…

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The first smallpox epidemic on the Canadian Plains: part 2

Morbidity and mortality were extremely high, but there is no satisfactory numerator and no denominator to calculate the rates of morbidity or mortality. Many or most Indians, whom the authors classed as ‘alive’ when first mentioned, be­tween December 4, 1780 and March 23, 1781 (often because they had not yet been exposed) soon became ill…

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The first smallpox epidemic on the Canadian Plains

The first smallpox epidemic on the Canadian Plains: In the fur-traders’ words Smallpox was brought to Mexico by the Spaniards in 1520. On each occasion it occurred in epidemic form, with ex­tremely high mortality among Aboriginal peoples who, in epi- demiological terms, were ‘virgin soil’. Smallpox reached Massachusetts in 1633 and the St Lawrence River…

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Osteoporosis in men: a study in patients affected by chronic non-advanced liver disease

Introduction Metabolic bone disease is a complication of chronic liver dis­ease (CLD) and is well known as “hepatic osteodistrophy”. Osteoporosis accounts for the majority of cases, whereas osteomalacia is rare in the absence of advanced liver disease and severe malabsorption. The prevalence is the same in men and women, however the published prevalence of os­teoporosis…

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Natural Course of Treated Pulmonary Embolism: DISCUSSION part 2

At variance with Pa02st and Ve, which tended to return toward normal as a consequence of the pro­gressive recovery of perfusion during the first week or the first month, the P(A-a)02, P(a-A)C02, and Vd/ Vt%, even after appropriate treatment, showed the persistence of some abnormalities six months later. The incomplete recovery of perfusion and of…

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