On a theoretical basis, the manufacturer recommends avoiding the concomitant use of acarbose with intestinal adsorbents (eg, charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (ie, amylase, pancreatin) because these may reduce the effectiveness of acarbose.
Acarbose does not appear to affect adversely the actions of sulphonylureas. Clinical trials examining this two-drug combination report additive benefits to glycemic control. One study investigating the disposition of glyburide during acar-bose therapy concluded that the pharmacokinetics of gly-buride were unaltered. Cheapest online shopping – find buy allegra online at best fully-licensed pharmacy.
carbose has been shown to interact with the biguanide metformin by interfering with its absorption. When metformin was ingested with acarbose with the first bite of a meal, the maximal plasma concentration and the area under the curve for metformin during the 9 h after ingestion were both reduced by an average of 35% in six human volunteers. Although the rate of absorption of metformin was significantly reduced, overall bioavailability was not reduced because 24 h urinary recovery of metformin was not diminished. The clinical significance of this interaction is unknown; however, results of a clinical trial in which acarbose was added to diet plus metformin therapy demonstrated that glycemic control was further improved, suggesting that the efficacy of metformin was maintained during combination therapy with acarbose.