Malignant eccrine poroma (eccrine porocarcino- ma) is a rare skin appendage tumor occurring on the intraepidermal ductal portion of eccrine sweat glands, first described by Pinkus and Mehregan in 1963. Five cases have been reported in Korean.

Most of the tumor cells showed negativity for carcinoembryonic antigens, whereas tumors forming the structures of vessels showed positivity. They showed negativity for S-100 protein and positivity for cytokeratin. We referred him to the department of urology for surgical excision. There has been no recurrence six months after the operation. literature since the initial two cases of immuno- histologic stain findings were reported by Sung et al in 1992. Malignant eccrine poroma occurs mainly in the aged. It can develop on any part of the body but is typically seen on lower extremities. Approximately 50% of all tumors develop on the lower extremities, among them the most common tumor sites are legs (30%) and feet (18%). Studying 120 cases of malignant eccrine poroma revealed that the leg is the most vulnerable site, followed by the foot, face, thigh and arm. Apparently the site of malignant eccrine poroma has nothing to do with the density of sweat glands. Although the palm and sole contain the highest densities of eccrine sweat glands, only one case reportedly involved the finger and palm and only seven cases involved the sole7. In this case, the tumor developed on the suprapubic area, which is a rare location in that only 5 such cases have been reported in English literature. Clinically, the disease displays visual symptoms like verrucous plaques and ulcerative nodules. If it is accompanied with multiple lesions, it suggests local recurrences or metastases to internal organs. Apcalis Oral Jelly

In cases where malignant eccrine poroma de­velops on benign eccrine poroma that has existed for a long time, anaplastic cells are to be discovered. They appear to be pathologically benign, carrying hyperchromic nuclei in large and irregular shapes and lying next to the basophilic uniform columnar cells of eccrine poroma. Other characteristic fea­tures include hyperkeratosis, acanthosis and cloned tumor cell nests that are different in shape and clearly separated from the surrounding squamous cells, which is called Jadassohn phenomenon. Care should be taken to differentiate it from other dermatological diseases such as benign eccrine poroma, seborrheic keratosis and Bowen’s disease. This case also includes marked clonal epidermal tumor cell nests and the infiltration of tumor cell nests into the dermis. Tumor cells have large nuclei with multiple atypical mitoses and cytoplasmic vacuoles. They are considered as an undifferentiated ductal portions of the eccrine sweat gland in the tumor cells. One of the most important findings in diagnosing malignant eccrine poroma is the ductal structures and cytoplasmic vacuoles surrounded by eosinophilic cuticles, which indicates eccrine differ­entiation .

Category: Diseases / Tags: Malignant eccrine poroma, Suprapubic area

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